Chip-DSC 10 – DSC of pharmaceuticals – Glass point sorbitol

Pharmaceutical sample – sorbitol – glass point

Differential Scanning Calorimetry (DSC) serves as a valuable instrument for the analysis of pharmaceuticals, playing a crucial role in quality control, research and development, and product characterization. Beyond the drug’s composition, its precise crystal structure and phase are pivotal factors outlined in patents. Even slight variations in humidity and composition can impact the structure, potentially transforming the product with altered modes of action.

App. Nr. 02-011-003 Chip DSC 10 – DSC of pharmaceuticals – Glass point sorbitol

In a specific instance, sorbitol, a synthetic C-6 sugar-alcohol commonly utilized as a sugar substitute in sweets, diet products, and as a carrier substance in pharmaceuticals, underwent investigation using Chip-DSC 10 with a quench cooler.

The objective of the measurement was to illustrate the influence of humidity on the product’s structure. Two samples were analyzed: one with 5.4% water content and another water-free sample. The measurement spanned from -70°C to 50°C. The results revealed a notable difference in the glass transition temperature of water-free sorbitol (depicted by the blue curve) at -3.9°C, as opposed to the sample containing 5.4% water (represented by the red curve) with a lowered glass transition temperature of -28.7°C. This shift in temperature may also impact the crystal structure of the solid and holds significance for the product’s storage conditions.

Related instruments

Chip-DSC 10

  • Perfect DSC for Quality control and Education
  • the mid-range DSC with interchangeable sensor
  • -180 up to 600°C (LN2 Quench cooling)
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